According to initial reports a man wielding an axe entered the station and injured two people.
Police were investigating the motive for the attack, she said.
Police said two suspected attackers have been arrested following the attack but more are thought to be on the run.
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Shocking images show injured passengers lying on the floor in the station, surrounded by paramedics.
Federal police spokesman for North Rhine-Wesphalia state, Rainer Kerstiens, told Deutsche Welle it appeared to be an attack and a search was still underway.
"Station closed. I am in the train thins look bad #police #terror", said Bruno Macedo, who witnessed the attack, in a tweet.
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He added: "Stay away from #Dusseldorf train station insane man with #axe on the lose".
The station has since been evacuated with a heavy police presence now on scene.
Trains are reportedly not stopping at the station.
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