The 24-year-old battled hard to be fit for the crunch trip to Old Trafford but failed to recover, and deputy Asmir Begovic was beaten by strikes from Marcus Rashford and Ander Herrera as the gap at the top of the Premier League was closed to just four points with rivals Tottenham also winning.
Antonio Conte has conceded that Tottenham Hotspurs are the best team in the Premier League right now, after losing 2-0 to Manchester United yesterday.
Conte said: "We didn't play a good game and United deserved to win the game".
"It is very simple but in this case the fault is of the coach".
Chelsea expect Thibaut Courtois to be fit to return from injury in time for the FA Cup semi-final on Saturday.
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"I think sometimes people say we're still second and Chelsea are still seven points clear - or four now - so they don't think we are doing as well as last season", Kane said.
The Frenchman, a highly criticised figure following defeats at Stamford Bridge earlier this season, sent a message to his doubters with a masterful display, characterised by an array of superb balls forward and driving runs from deep.
Referencing that quarter-final clash, Mourinho said: "That game was totally controlled when we played with 11 players, and only the decision that made us play with 10 players gave Chelsea a chance to be dominant".
In fielding an unorthodox 3-5-2 system and charging two players with man-marking jobs, Mourinho showed his famed tactical acumen has not deserted him - and blew the Premier League title race wide open.
"For this reason we must have great enthusiasm to play these last six games".
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"I don't feel extra joy at beating Chelsea - we beat the leader".
"We have to react in the right way", he said.
So, according to Conte, we have a Chelsea side lacking motivation and a Tottenham team that are the best in the country and with a chance of glory.
"It was a special game, an important one, and despite being in the stands I enjoyed the great atmosphere at Old Trafford and my team-mates' great performance".
"We don't know what can happen in the Europa League, so these three points were phenomenal. We can be very happy".
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Of course, Spurs are still the one chasing and we're the one "safe", but the fact that we were unable to respond to their victory over Bournemouth really makes things lot more interesting. "Be patient and have great will to fight. otherwise we must clap another team", he added.